DES in the US
https://www.jacksonlees.co.uk/broudiejacksoncanter/services/des-justice-uk/des-us
In 1941, the US Food and Drug Administration (FDA) approved Diethylstilbestrol (DES) as a treatment for menopausal symptoms, postpartum lactation suppression, gonorrhoeal vaginitis, and atrophic vaginitis.