DES Grandchildren (Third Generation): There are ongoing questions about whether the effects of DES exposure can be passed to subsequent generations through epigenetic changes. Animal studies in mice have shown third-generation effects, like elevated tumours. Preliminary data suggests DES granddaughters may have higher risks of infertility or menstrual irregularities, and DES grandsons may have increased rates of hypospadias.  

For example, a 2011 French cohort study found a modest increase in hypospadias among boys whose grandmothers took DES. These findings, based on small sample sizes, are not conclusive. Researchers are monitoring DES-exposed families for transgenerational effects. Currently, no specific screening is recommended for DES grandchildren, but research continues.

If you’ve been affected and want to connect with others who understand what you’re going through, we encourage you to join a private and supportive Facebook group — run and moderated by a DES Daughter. It’s a safe space where you can share your experiences, ask questions, and find solidarity. You can also help us understand your situation better by completing our confidential client questionnaire.

Fill in our client questionnaire

Your voice matters, and we’re here to support you every step of the way.